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  • Authors: Allen, Jonathan Edward (2006)

  • Obtaining the complete set of proteins for each eukaryotic organism is an important step in the quest to understand how life evolves and functions. The complex physiology of eukaryotic cells, however, makes direct observation of proteins and their parent genes difficult to achieve. An organism's genome provides the raw data that contains the set of instructions for generating the complete set of proteins, providing the potential to obtain a complete list of proteins without having to rely exclusively on direct observations in the cell. Computational gene prediction systems, therefore, play an important role in compiling sets of putative proteins for each sequenced genome. This dissertation addresses the problem of computational gene prediction in eukaryotic genomes, presenting a fr...