ThesisAuthors: Fleckenstein, Anne E. (2006)
Multiple drug resistance is quickly becoming an obstacle to the treatment of disease. Bacteria, parasitic protazoa, yeast and mammalian cancer cells develop mutations that render them resistant to a wide variety of structurally and chemically different compounds.
In the yeast Saccharomyces cerevisiae, one of the main mechanisms causing drug resistance is the loss of function of ABC transporters that are responsible for effluxing the drug from the cell. The main ABC transporter responsible for efflux of many different drugs is Pdr5p. However, earlier work (Fleckenstein et.al. 1999; Shallom and Golin, 1996) shows that this is not the only pathway mediating resistance to these drugs. The global regulator Sin4p and the transcription factor YRRI operate in a PDR5-independent pathway to ... 
