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  • Authors: Lin, Li (2005)

  • Curcumin is the major yellow pigment isolated from the rhizome of Curcuma longa, known as turmeric. Over a long period of study, curcumin has been found to possess a wide range of bioactivities including anti-prostate cancer activity in vitro and in vivo. Based on these observations, our laboratory has been using curcumin as the lead compound to develop various analogs as potential anti-prostate cancer agents. Two curcumin analogs, dimethyl curcumin (DMC, 4) and 4-ethoxycarbonylethyl curcumin (ECECur, 5) developed previously were found to be active anti-androgen receptor agents, which showed greater potency than hydroxyflutamide, an anti-androgen currently used clinically. However, the tautomerism of ECECur, which causes it to exist in both enol-keto and di-keto forms, may hinder it...