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  • Authors: Ghosh, Ronojoy (2005)

  • Recent advances in quantitative biology have created a tremendous opportunity to apply dynamical systems modeling to biological phenomena, and to validate these models using experimental data. Using simulation and analysis, there is immense scope to discover non-intuitive design principles behind biological processes, and successfully predict the effects of changing key variables. Systems biology, defined as the integration of mathematical analysis with experimental biology, has the potential to revolutionize the way biology is done. Cellular protein signaling networks exhibit complex combinations of both discrete and continuous behaviors. The dynamics that govern the spatial and temporal in-crease or decrease of protein concentrations inside cells are continuous differential equat...