Ấn phẩm:
Genomic insights into multidrug-resistance and virulence in a vancomycin-resistant Staphylococcus aureus strain VR480
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Tóm tắt
Vancomycin-resistant Staphylococcus aureus (VRSA), a “high priority antibiotic-resistant pathogen”, is emerging and threatening global health. Nevertheless, molecular mechanisms associated with virulence and multidrug resistance in VRSA are not fully investigated particularly in low- and middle-income countries. Here, for the first time, the complete genome of a VRSA strain VR480 isolated from a Vietnamese patient was generated by the combination of long- and short-read sequencing technologies. The VRSA strain VR480 was a multidrug-resistant phenotype with resistance to at least one antibiotic belonging to beta lactams, quinolones, lincomycin, oxazolidinones, tetracyclines, glycylcyclines, macrolide/lincosamide/streptogramin, nitrofurans, rifamycins, sulfonamides and glycopeptides. This strain was classified as vancomycin resistance (MIC ≥ 32 μg/mL). VRSA strain VR480 belonged to sequence type ST2779 and carried the SCCmec type II(2A). The VRSA strain VR480 genome contains five resistance mutations in genes. gyrA S84L, parC S80F, parE D432N, fusA L461K and glpT W355Stop, and eleven antibiotic resistant genes including mecA, mecR, mecI, tetM, tet38, mepA, lmrS, ant(9), ermA, fosB and catA.
Mô tả
Academia Journal of Biology, Vol. 46, No. 2
Tác giả
Nguyen, Quang Huy
Nguyen, Thai Son
Nguyen, Thai Uyen Thu
Nguyen, Thuy Duong
Tran, Thi Thanh Tam
Người hướng dẫn
Nơi xuất bản
Nhà xuất bản
Viện Sinh thái và Tài nguyên sinh vật, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
Năm xuất bản
2024-06
ISSN tạp chí
Nhan đề tập
Từ khóa chủ đề
Antibiotic resistance , Protein interaction network , Staphylococcus aureus , Vancomycin resistance , Whole genome sequencing , Virulence
URI
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Tệp tin
Nguyen Quang Huy, Nguyen Thai Son, Nguyen Thai Uyen Thu, Nguyen Thuy Duong, Tran Thi Thanh Tam.pdf
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