Ấn phẩm:
Evolutionary characterization of clades 2.3.4.4 H5N6 and 2.3.2.1c H5N1 HPAI viruses in Vietnam (2013–2019) revealed distinct reassortants from distant spillovers
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Tóm tắt
Highly pathogenic avian influenza (HPAI) H5Nx viruses have continually undergone multiple evolutionary dynamics for the generation of various clades, subclades, and genotypes where 2.3.2.2c, and 2.3.4.4 become predominant and co-circulating in Vietnam from 2014 to date. In this study, fifteen H5 sequences in our study and 90 from others from different clades, 0, 1, 1.1, 2.3.2.1a, 2.3.2.1c, 2.3.4, 2.3.4.1, 2.3.4.2, 2.3.4.3 and 2.3.4.4 of H5N1, H5N2, H5N6, were characterized for hemagglutinin (HA) properties, genetic and phylogenetic analyses. Blast searching using the dataset of the full length of two H5N6 viruses revealed one strain, e.g., A/Duck/Vietnam/HT7/2014(H5N6) in May 2014, belonging to the Sichuan 2014-lineage of Group D (Minor). The other strain, A/Chicken/Vietnam/NT3/2017(H5N6)/or CkNT3-2017 in the Spring of 2017, belonged to the Japanese-Korean late 2016-cluster of Group C (Major). This cluster possessed 140NHETS-145del stretch ofLeucine/Serine deletion at position 145 in HA1 (S/L145del), distinct from all the 2.3.4.4 H5N6 viruses known to date. There has been no report of the similar CkNT3-2017 of 2.3.4.4 reassortant in Vietnam prior to our study. The migration flyway might be the route for transportation of this novel H5N6 virus from Japan to Vietnam.
Mô tả
Vietnam Journal of Biotechnology, Vol. 20, No. 2
Tác giả
Nguyen, Trung Nam
Nguyen, Hung Chi
Chu, Hoang Ha
Do, Thi Roan
Nguyen, Thi Bich Nga
Le, Thanh Hoa
Người hướng dẫn
Nơi xuất bản
Nhà xuất bản
Viện Công nghệ sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
Năm xuất bản
2022-06
ISSN tạp chí
Nhan đề tập
Từ khóa chủ đề
Avian influenza , H5N6 viruses , H5N1 viruses , Phylogenetic analysis
URI
Tài liệu tham khảo
Thông tin bản quyền
Tệp tin
Nguyen Trung Nam, Nguyen Hung Chi, Chu Hoang Ha, Do Thi Roan, Nguyen Thi Bich Nga, Le Thanh Hoa.pdf
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