Ấn phẩm:
Characterization of zoonotic hepatitis E virus in domestic pigs and wild boar in Vietnam: Implications for public health
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Vietnam’s unprecedented demand for meat from livestock, including pigs and farmed wildlife, underscores the
importance of understanding zoonotic reservoirs for hepatitis E virus (HEV). This study aimed to identify and
characterize circulating zoonotic HEV in domestic pigs and wild boar to understand genotype frequencies,
transmission dynamics, and associated human health burdens. Rectal swabs, feces, and liver samples from 415
pigs and 102 wild boars were collected across various farms and slaughterhouses in central and southern
Vietnam and screened for HEV RNA using nested PCR. HEV RNA-positive samples underwent sanger sequencing
and genotyping. Overall, 10% (n = 54/517) of samples were HEV RNA-positive, with wild boars exhibiting the
highest HEV positivity rate at 25%, followed by domestic pigs at 7%. Southern Vietnam showed a higher HEV
RNA positivity rate (20%) compared to central Vietnam (7%). Notably, rectal swabs demonstrated the highest
positivity rate (15%), followed by feces (8%) and liver (4%). HEV-3a was the predominant genotype at 85%,
followed by HEV-4b at 9% and HEV-3f at 6%. While HEV-3a was distributed across both central and southern
Vietnam, HEV-3f was exclusively detected in central Vietnam, and HEV-4b was identified in wild boar in
southern Vietnam. These findings underscore the substantial prevalence of HEV in wild boars, emphasizing their
potential as crucial zoonotic reservoirs alongside domestic pigs. Further investigations involving occupationally
exposed individuals in high-prevalence areas are warranted to evaluate the human health impact of zoonotic
hepatitis E and inform preventive measures. Regular epidemiological studies are imperative for assessing the
prevalence and transmission of zoonotic HEV infections among common reservoirs, thereby aiding in the prevention of spillover events within the community.
Tác giả
Cao, Le Chi
[et al.]
Người hướng dẫn
Nơi xuất bản
Nhà xuất bản
Năm xuất bản
2024
ISSN tạp chí
Nhan đề tập
Từ khóa chủ đề
Health care
Bộ sưu tập
URI
Tài liệu tham khảo
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Tệp tin
Characterization of zoonotic hepatitis.pdf
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