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New synthetic methods for hypericum natural products
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In this dissertation, we have investigated the direct and efficient synthetic route to biologically active natural products.
Chapter 1 describes a concise and efficient synthetic route to the highly funtionalized tricyclic core skeleton of papuaforin B. In the course of the synthesis, an efficient cyclization method using Na/NH3 was demonstrated. Newly developed bromination method leading to an a-bromoenone would serve as a handle for construction of the fused pyran ring of papuaforin B. Further efforts along this line are in progress.
Chapter 2 describes the direct synthesis of 7,8-dihydroxycalamenene, which includes the successful application of allylic strain in the stereoselective synthesis. Interestingly, Mansonone C, a potent antifungal agent, was also obtained as the co-product from the same starting material. Application of this synthetic strategy to the synthesis of analog natural products is in progress.
Tác giả
Jeon, Insik
Người hướng dẫn
Nơi xuất bản
Nhà xuất bản
Iowa State University
Năm xuất bản
2006
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Từ khóa chủ đề
Thực vật học , Cây nọc sởi , Sản phẩm tự nhiên