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Facilitation of protein three-dimensional structure determination using enhanced peptide amide deuterium exchange mass spectrometry (DXMS)
Three dimensional structure determination and analysis of proteins is necessary for the understanding of how proteins participate in human disease, and are critical for the effective design of therapeutics for clinically important targets. Current efforts for determining protein structures are centered on novel high-throughput (HT) approaches. These include high throughput (HT) crystallization efforts and global structure prediction efforts monitored through the Critical Assessment of Structure Prediction (CASP) experiments where progress has been incremental at best. Protein structure analysis of conformational changes and protein-proteins interactions can be monitored by biophysica...
We present a generative graphical model and stochastic filtering algorithm for simulta¬neous tracking of 3D rigid and nonrigid motion, object texture, and background texture from single-camera video. The inference procedure takes advantage of the conditionally Gaussian nature of the model using Rao-Blackwellized particle filtering, which involves Monte Carlo sampling of the nonlinear component of the process and exact filtering of the linear Gaussian component. The smoothness of image sequences in time and space is exploited using Gauss-Newton optimization and Laplace’s method to generate proposal distributions for importance sampling. Our system encompasses an entire continuum from ...
Events occur in every aspect of our lives. An unexpectedly large number of events occurring within some certain measurement (e.g. within some time du-ration or a spatial region) is called a burst, suggesting unusual behaviors or activities. Bursts come up in many natural and social processes. It is a challenging task to monitor the occurrence of bursts whose lasting duration is unknown in a fast data stream environment. This work describes efficient data structures and algorithms for high performance burst detection under different settings. Our view is that bursts, as unusual phenomena, constitute a useful preliminary primitive in a knowledge discovery hierarchy. Our intent is to bu...
Fate, transport, and environmental availability of copper(II) applied in catfish aquaculture ponds and enhanced immobilization of soil-bound lead using a new class of stabilized iron phosphate nanoparticles
Copper sulfate has been the most commonly used algaecide for about a century in the U.S. to control the off-flavor problem caused by blue-green algae in channel catfish (Ictalurus punctatus) ponds. In 2001, the ~80,000 hectares of channel catfish ponds in the U.S. received a total dose of 4,000,000 kg of CuSO4•5H2O or 1,000,000 kg of Cu2+. However, no detailed studies have been available pertaining to the potential adverse impacts of the copper applied in catfish ponds on human and environmental health. A pilot-scale study and various field measurements at commercial ponds were conducted to investigate the environmental fate of copper applied as an algaecide in catfish ponds. In the ...
Fault diagnosis of induction motors using signal processing based methods and optimal feature selection
Fault detection and diagnosis in rotating machines have been used widely in commercial systems over the past few decades. Numerous works on machine conditions have been implemented with the aid of the MCSA (Motor Current Signature Analysis) method, the vibration-based methods, etc. The purpose of these methods is to detect and diagnose faults in an early stage and therefore allow contingency plans to be put into place before the problems worsen. The dynamic and vibratory behaviours of the machine, such as vibration, sound, and temperature… are affected if the running condition is changed. The behaviours can be useful indicators to detect problems within the machine as they vary abnorm...
An introduction to the journal is presented in which the editor discusses the effect economic conditions in 2010 will have on business, economic forecasting, and what trends will shape 2011
Many companies in mature markets assume that the only reason to enter emerging markets is to pursue new customers. They haven’t yet realized the potential for innovation in developing countries _ though a few visionary multinationals are tapping that potential for much – needed ideas in products and service. General electric, with its portable ultrasound technology, and intel, with its inexpensive classmate PC, are two examples. Other companies see the potential but find it hugely difficult to develop ideas in unfamiliar settings, much less turn them into global businesses: C_Level executives may resist disruptive concepts, or their organizations may lack the processes necessary for a...
Fixed-film anaerobic digestion: Mechanisms of pathogen reduction and impacts on virus adsorption to soil
Anaerobic digesters have been used for treatment of various wastewaters. Systems are usually operated at mesophilic (35°C) temperatures and long hydraulic retention times (HRTs) (> 20 days). Pathogen reduction during anaerobic digestion is mainly correlated with operating temperature and HRT. Higher temperatures and longer HRTs result in increased rates of pathogen decimation. Previous studies show that a novel fixed-film anaerobic digester, operated at a low HRT (< 3 days) and ambient temperature (< 28°C) treating flushed dairy manure wastewater, achieved significant reductions of indicator and pathogenic bacteria. Thus, we sought to determine factors that contributed to indicator...
The article discusses the characteristics of effective educators and the central role strong teaching plays in student success. The author examines key aspects of engaging teaching methods such as making the educational needs of students a top priority, making subjects interesting and engaging for students, and allowing teachers to employ a variety of strategies to reach students with different learning styles. An explanation of teacher workshops relating to developing effective teaching techniques, an examination of public opinion regarding the importance of teachers, and an evaluation of educational legislation such as the 2001 No Child Left Behind Act are also included.
The article discusses business education at U.S. universities and examines reasons why statistics regarding the amount of time students spend studying and preparing for courses show that undergraduate business students are generally disengaged. It explores the problem solving and critical thinking skills that employers seek when hiring college graduates and describes the business education structure at schools such as Radford University, Ohio University, and the University of Virginia. Other topics include the book "Academically Adrift: Limited Learning on College Campuses" by Richard Arum and Josipa Roska, the Collegiate Learning Assessment (CLA) national standardized essay test, and...
Franz Boas: Lịch sử văn hóa cho hiện tại, hay lịch sử tự nhiên đã lỗi thời? = “Franz Boas: cultural history for the present, or obsolete natural history?”
Gần đây,một số nhà nhân học theo trường phái tân Boas (neo-Boasian anthropologists) mô tả Boas như một nhà nhân học với cảm nhận sâu sắc về lịch sử,về cá nhân và chủ thể.Nghiên cứu sâu thực hành dân tộc học của Boas chứ không tập trung vào những tuyên bố lý thuyết và khái quát của ông, trước hết, tôi thấy ông là một nhà dân tộc học quan tâm đến nguyên tửluận (trái ngược với chính thể luận),và một sự hội tụ sâu sắc giữa nghiên cứu các vấn đề tiểu tiết này và lịch sử tự nhiên theo kiểu Linnaean.Theo diễn giải của Foucault Jacob về lịch sửtự nhiên, điều này có nghĩa là nghiên cứu hiện tượng văn hóa xã hội thông qua những biểu hiện bên ngoài, và làm mất đi tính lịch sử, thậm chí cả những...
From Good Intentions to Proven Interventions: Effectiveness of Actions to Reduce the Health Impacts of Air Pollution
Associations between air pollution and a multitude of health effects are now well established. Given ubiquitous exposure to some level of air pollution. An international multidisciplinary workshop was convened to discuss evidence of the effectiveness of actions to reduce health impacts of air pollution at both the community ad individual level. The overall aim was to summarize current knowledge regarding air pollutions exposure and health impacts leading to public health recommendations.