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  • Authors: Chen, Ting (2006)

    One of the hallmarks of the eukaryotic cell is the possession of a nuclear envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments is mainly regulated by the small GTPase, Ran. The nucleotide exchange factor RCC1 catalyzes formation of RanGTP, whereas the hydrolysis of RanGTP is stimulated by RanGAP1 and RanBP1. Because RCC1 is chromatin-bound throughout the cell cycle while RanGAP1 and RanBP1 are cytoplasmic, the concentration of RanGTP is high near the chromatin. This RanGTP gradient is essential for many cellular processes, including nuclear transport during interphase, mitotic spindle formation, and nuclear envelope assembly during mitosis. During t...