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Browsing by Author Sun, Zheng

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  • Authors: Sun, Zheng (2006)

    The I1-imidazoline receptor is a novel target of drug development for hypertension and insulin resistance. This thesis focused on the molecular basis for I1-imidazoline binding and cell signaling and the mechanisms linking this signaling protein to regulation glucose metabolism. IRAS is a gene candidate for the I1-imidazoline receptor. To investigate the possibility that IRAS is the I1-imidazoline receptor, antisense oligo-nucleotides directly against the initiation site of IRAS sequence were designed and transfected into PC12 cells. Antisense transfection for 48h reduced specific imidazoline radioligand binding to plasma membrane fractions by about 50%, with parallel drops in IRAS pr...