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Browsing by Author Zhang, Wei

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    • Sex determination in Drosophila: Biochemical and functional studies of transcription factor doublesex
    Authors: Zhang, Wei (2006)

    Doublesex (dsx) and dsx-related genes encode a novel class of transcription factors conserved among metazoans. The members of this family play a critical role in sex differentiation across species from Caenorhabditis elegans to humans. Mutations or deletions of these genes are associated with intersexual abnormalities, including a class of human birth defects termed "9p syndrome". This thesis is focused on the dsx gene from Drosophila melanogaster, the archetype of this class. Sex-specific RNA splicing leads to male and female isoforms, designated DSXM and DSXF. Biochemical and genetic studies of the DM domain and the female-specific C-terminal domain are presented. The importance of ...
    • Synthetic studies toward the total synthesis of amphidinolide B1
    Authors: Zhang, Wei (2006)

    As one of the most potent cytotoxic compounds of amphidinolide family, amphidinolide B1 was isolated from a culture of amphidinium genus free-swimming dinoflagellate.l In addition to its intriguing bioactivity, amphidinolide B1 has some attractive structural features including a C13-C15 highly substituted diene, an unusual allyl epoxide moiety, nine stereocenters and 26-membered macrolactone skeleton. Although numerous synthetic efforts toward the total synthesis of amphidinolide B1 have been published, it remains an unconquered target. In our synthetic study, many useful protocols have been developed. To establish the C13-C15 diene, we applied a novel Fleming-type coupling and subse...