Browsing by Author White, Elizabeth A.

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  • Authors: White, Elizabeth A. (2006)

    The human cytomegalovirus (HCMV) IE2 86 kDa protein is an essential viral regulatory factor that has been shown in transient transfection and in vitro assays to transactivate early viral promoters and to interact with many viral and celular proteins. To understand the functions provided by this protein in the HCMV-infected cel, we have constructed and characterized a family of recombinant viruses containing changes to the IE2 gene and other parts of the HCMV major immediate early (IE) region. The study of these HCMV mutants has alowed us to confirm that several of the predicted functions of IE2 86 are relevant in the virus-infected cel and has identified new functions for the protein...