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Synthesis of novel heterocycles for drug discovery using radical cascade reactions

Authors: Wang, Chih Hung (2006)

This dissertation describes efforts towards the assembling of structurally diversified heterocycles using radical chemistry. Reaction mechanisms for the formation of these novel compounds and their structural analysis are also presented. Furthermore, we describe the success we have achieved in eantioselective syntheses that transfer chirality from the radical precursor to the newly formed stereocenter(s) in the products during radical reactions. The novel compounds that have been prepared could possibly serve as pharmacophores in drug discovery projects.

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Browsing by Author Wang, Chih Hung