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  • NR15522.PDF.jpg
  • Thesis

  • Authors: Bainbridge, Shannon Amber (2006)

  • Pre-eclampsia (PE) is a disorder of pregnancy affecting 5-7% of all pregnancies, characterized by maternal hypertension and proteinuria. Interestingly, women who smoke cigarettes throughout gestation are 33% less likely to develop this disorder than non-smoking women. The specific mechanisms through which cigarettes confer protection from PE are unknown; however the reduced risk for PE has been strictly associated with the combustible products of tobacco. It is postulated that carbon monoxide (CO), a major component of cigarette smoke, may play a vital role in this association as CO has been shown to possess several regulatory and cytoprotective properties. The enzyme responsible for ...